Oxidative stress markers and antioxidant defense in hibernating common Asian toads, Duttaphrynus melanostictus

Oxidative stress markers and antioxidant defense in hibernating common Asian toads, Duttaphrynus melanostictus

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To assess the oxidative assaults and antioxidant defense, oxidative stress markers, including lipid peroxidation level, protein carbonylation level, GSSG/GSH ratio and nonenzymatic antioxidants such as total glutathione, ascorbic acid and uric Baby Cold Cereals acid, in liver and brain tissues of hibernating common Asian toads, Duttaphrynus melanostictus, were compared with toads during active periods.Oxidative stress was found in both liver and brain tissues of hibernating common Asian toads in spite of depressed metabolism and low oxygen consumption.Significantly higher lipid peroxidation, protein carbonylation and an increased GSSG/GSH ratio were found in liver and brain tissues of hibernating toads, indicating oxidative stress.

To counteract the stress, ascorbic acid was increased significantly in the liver and brain tissues of hibernating individuals in comparison to individuals during active periods.The uric acid level decreased in both the liver and brain tissues of hibernating toads, which may be due to its decreased Figure Skating - Skates - Mens rate of synthesis because of low xanthine oxidase activity at low body temperature and hypometabolism.The common Asian toad faced oxidative stress during hibernation, which was counteracted by augmented nonenzymatic antioxidant defense.